$1. $ Despite her tiredness, she managed to finish her work on time

$→$ Although + S + V,…….

$→$ Despite/In spite of + Noun/Noun Phrase/V-ing, S + V + …

$→$ Despite / In spite of : mặc dù (đi với một cụm danh từ)

$→$ Vì Despite đi với một cụm danh từ nên ta chuyển : 

$→$ She was tired $→$ her tiredness

`@Chamian`

$\text{46.}$ Although she was tired, she managed to finish her work on time.

$\Rightarrow$ Despite her tiredness, she managed to finish her work on time .

$\Rightarrow$ Although + S + clause , S + clause ( although : mặc dù ) 

$\Rightarrow$ Despite/In spite of + Noun/Noun Phrase/V-ing , S + clause 

$\Rightarrow$ was tired chuyển sang tiredness (n) : mệt mỏi